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This work was supported by National Institutes of Health Grants MH101491, AG051807, and AG050787 to M.A.W., the National Institute on Aging Grants F32 AG052303 and K99 AG056596 to J.L.K., and in part by the Intramural Research Program of the National Institute on Aging. We thank Dr. Timothy Bredy for his help developing the HA-Nr4a1 virus.The emphasis here is on the lines available as opposed to methods on how to develop transgenic mice, which has been discussed in detail previously (Doyle et al., 2012). Additionally, we will discuss other genetic tools available to neuroscientists, such as siRNAs, viral-mediated approaches, and variations of the CRISPR-Cas9 system.Timothy J. Jarome, Janine L. Kwapis, Jada J. Hallengren, et al. long-term memory formation The ubiquitin-specific protease 14 (USP14) is a critical regulator ofLike reconsolidation, NMDA receptor activation is critical for memory extinction (Kwapis, Jarome, Lee, Gilmartin, & Helmstetter, 2014). Stimulation of β-adrenergic receptors by noradrenaline is known to potentiate fear memory extinction (Berlau & McGaugh, 2006; Mueller, Porter, & Quirk, 2008), while their inhibition by propranolol impairs it ...Janine L Kwapis 1 2 , Yasaman Alaghband 1 , Alberto J López 1 , André O White 3 , Rianne R Campbell 1 , Richard T Dang 1 , Diane Rhee 1 , Ashley V Tran 1 , Allison E Carl 1 , Dina P Matheos 1 , Marcelo A Wood 1 2Figure 3. TetTag and TRAP systems allow neurons active during specific time windows to be persistently tagged. (A) Tet-tag system. Two transgenes control tagging of active neurons: 1) tTA under the control of the activity-dependent cFos promoter and a TetO promoter that drives both the gene of interest (e.g. a reporter gene) and the dox-insensitive tTA* mutant that drives persistent expression ...Marcelo A. Wood,1,2 and Janine L. Kwapis1,2 1Department of Neurobiology and Behavior, University of California, Irvine, California, 92697, USA; ... (McQuown et al. 2011; Kwapis et al. 2017). To verify the presence of the mutant transgene in BAF53bΔSB2 mice, punches (1.0 µm diameter) were also collected from areaAuthor links open overlay panel Yasaman Alaghband a b c, Janine L. Kwapis a b d, Alberto J. López a b c, André O. White a b c 1, Osasumwen V. Aimiuwu a b c 2, ... Kwapis et al. (2017) demonstrated that indeed the enzymatic activity of HDAC3 is required for amygdala-dependent forms of memory formation.Janine L. Kwapis, Department of Neurobiology and Behavior, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. UC Irvine Center for Addiction Neuroscience, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. Search for more papers by this author.Brief Communication Deleting HDAC3 rescues long-term memory impairments induced by disruption of the neuron-specific chromatin remodeling subunit BAF53b Guanhua Shu,1,2 Enikö A. Kramár,1,2 Alberto J. López,1,2 Grace Huynh,1,2 Marcelo A. Wood,1,2 and Janine L. Kwapis1,2 ...12 Okt 2022 ... ... Janine L. Kwapis. doi: https://doi.org/10.1101/2022.10.11.511798. This article is a preprint and has not been certified by peer review [what ...Jarome, Timothy J. ; Kwapis, Janine L. / Special issue "molecular mechanisms of memory formation and modification ...30 Agu 2013 ... Jarome , Janine L. Kwapis , Wendy L. Ruenzel and Fred J. Helmstetter*. Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee ...Undergraduate Research and Fellowships Mentoring Office. 321 Boucke Building. University Park, PA 16802. 814-863-8199 | [email protected]: 10.1016/j.neubiorev.2019.12.013 Corpus ID: 209352174; A neuroscientist's guide to transgenic mice and other genetic tools @article{Navabpour2019ANG, title={A neuroscientist's guide to transgenic mice and other genetic tools}, author={Shaghayegh Navabpour and Janine L. Kwapis and Timothy J Jarome}, journal={Neuroscience \& Biobehavioral Reviews}, year={2019}, volume={108}, pages={732 ...Janine Lynn Kwapis Doctorate Assistant Professor Primary The Pennsylvania State University (PSU) University Park, United States Post Doctoral Researcher University of …Janine L Kwapis 1 , Timothy J Jarome, Janet C Schiff, Fred J Helmstetter. Affiliation 1 Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA. PMID: 22028394 PMCID: PMC3207254 DOI: 10.1101/lm.023945.111 Abstract Memory for delay fear conditioning requires the synthesis of new mRNA and protein in the ...AU - Kwapis, Janine L. AU - Helmstetter, Fred J. N1 - Funding Information: This research was supported by the National Institute of Mental Health (NIMH) Grants R01MH069558 and R03MH090426 to Fred J. Helmstetter and NIMH Grant F32MH083422 to Marieke R. Gilmartin. We would like to thank Mary Lonergan for assistance with the drug microinjections.Hannah M. Boyd1, Megan J. von Abo1, Istvan Albert2,3, Janine L. Kwapis1,* 1 Department of Biology, Pennsylvania State University, University Park, PA 16802, USA 2 Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA 3 Department of Biochemistry and Molecular Biology,A variety of stressful experiences can influence the ability to form and subsequently inhibit fear memory. While nonsocial stress can impact fear learning and memory throughout the lifespan, psychosocial stressors that involve negative social experiences or changes to the social environment have a disproportionately high impact during adolescence.The broad goal of the proposed project is to understand how long-term memories are stored in the brain through the activity of protein kinase Mzeta (PKM?). Using rats, this project will determine the...Janine L Kwapis; Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during ...Janine Kwapis is a professor in the Biological Sciences department at Penn State University - see what their students are saying about them or leave a ...Europe PMC is an archive of life sciences journal literature.Author links open overlay panel Sydney Trask a, Nicole C. Ferrara b, Aaron M. Jasnow c, Janine L. Kwapis d. Show more. Add to Mendeley. Share. ... J.L. Kwapis et al. The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning. Neurobiol. Learn. Mem. (2015)Janine L. Kwapis Present address: Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, PA, 16802, USA ...Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association. The NR2B subunit confers unique properties to …1. To whom all correspondence should be addressed: Janine L. Kwapis, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA; e-mail: [email protected]. Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory ConsolidationChristopher W. Butler, Ashley A. Keiser, Janine L. Kwapis, Nicole C. Berchtold, Vanessa L. Wall, Marcelo A. Wood, Carl W. CotmanKwapis, Janine L Alaghband, Yasaman López, Alberto J et al. Publication Date 2017-05-01 DOI 10.1038/npp.2016.274 Peer reviewed eScholarship.org Powered by the California Digital Library University of Californiastudies the epigenetic and molecular basis of long-term memory, particularly how these mechanisms are altered in the aging brain and how epigenetic regulation of circadian genes might contribute to age-related memory decline.Semantic Scholar extracted view of "PKMζ maintains remote contextual fear memory by inhibiting GluA2-dependent AMPA receptor endocytosis in the prelimbic cortex" by L. A. Marcondes et al.Janine L. Kwapis [email protected] Department of Biology, Center for Molecular Investigation of Neurological Disorders (CMIND), Pennsylvania State University, University Park, Pennsylvania. Corresponding author: [email protected] Search for more papers by this author. Destiny S. Wright, Destiny S. Wright.Normal aging is accompanied by cognitive impairments, most notably disruptions in memory formation and updating, the ability to incorporate new information into existing memory. As lifespans increase...Trachsel L., Edgar D. M., Seidel W. F., Heller H. C., Dement W. C., Sleep homeostasis in suprachiasmatic nuclei-lesioned rats: Effects of sleep deprivation and triazolam administration. ... Janine L. Kwapis, The clock gene Per1 is necessary in the retrosplenial cortex—but not in the suprachiasmatic nucleus—for incidental learning in young ...The past decade has produced an explosion in the number and variety of genetic tools available to neuroscientists, resulting in an unprecedented ability to precisely manipulate the genome and epigenome in behaving animals.Janine L. Kwapis. Department of Neurobiology and Behavior, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. UC Irvine Center for Addiction Neuroscience, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. Search for more papers by this author. Monica Espinoza, Monica Espinoza.The Editors depend heavily on outside reviewers in forming opinions about papers submitted to JNeurosci and would like to formally thank the following individuals for their help during the past year.. Esther Aarts. Ishmail Abdus-Saboor. Ted Abel. Moshe AbelesHannah M. Boyd1, Megan J. von Abo1, Istvan Albert2,3, Janine L. Kwapis1,* 1 Department of Biology, Pennsylvania State University, University Park, PA 16802, USA 2 Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA 3 Department of Biochemistry and Molecular Biology,M. Nonet. Biology. bioRxiv. 2023. TLDR. The rRMCE toolbox provides a platform for developing further innovative uses of RMCE to create complex genetically engineered tools, and genetic and molecular reagents designed to facilitate customization of both targeting vectors and landing sites are described. 1.Mark W Urban 1 , Chenyu Lo 1 , Kasuni K Bodinayake 1 , Chad A Brunswick 1 , Shoko Murakami 1 , Ashley C Heimann 1 , Janine L Kwapis 2 Affiliations 1 Department of Biology, Pennsylvania State University, University Park, PA 16802, USA.Timothy J Jarome, Craig T. Werner, Janine L. Kwapis, F. Helmstetter Biology, Psychology PloS one 2011 TLDR Evidence is provided that UPS-mediated protein degradation is a major regulator of synaptic plasticity necessary for the formation and stability of long ... Janine L. Kwapis ValeriaLallai MichaelS. Landy FionaE. N. LeBeau Janine Kwapis Page 2 • First Place Award f Brain derived neurotropic factor (BDNF) supports neuronal survival, growth, and differentiation and is involved in forms of hippocampus-dependent and independent learning, as well as hippocampus-dependent learning. Extinction learning comprises active inhibition of no-longer relevant learned information, in conjunction with a decreased response of a previously learned behavior. It is highly ... Janine L Kwapis; Both the circadian clock and sex hor Janine L. Kwapis and Marcelo A. Wood Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697, USA Post-traumatic stress disorder (PTSD) and other anxiety disorders stemming from dysregulated fear memory are problematic and costly. Understanding the molecular mechanismsWhile the anterior cingulate (ACC) and retrosplenial (RSC) cortices have been extensively studied for their role in spatial navigation, less is known about how they contribute to associative learning and later memory recall. Europe PMC is an archive of life sciences ...